WebJan 18, 2024 · VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. The AAA+-type ATPase p97 governs an ever-expanding number of cellular … WebHere we find that compounds that activate the D1 ATPase activity of VCP/p97 fulfill these requirements. Such effects are seen with small molecule VCP activators like SMER28, which activate autophagosome biogenesis by enhancing interactions of PI3K complex components to increase PI(3)P production, and also accelerate VCP-dependent …
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WebValosin-containing protein ( VCP) or transitional endoplasmic reticulum ATPase ( TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. [5] … WebDihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines shuttlex串流
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WebDec 10, 2016 · This protein is a ubiquitin recognition factor protein which resides on the cytosolic side of ER membrane and forms a complex with the ubiquitin fusion degradation protein 1 (UFD1L, see below) and the valosin-containing protein (VCP, see below), also called p97 . A deficiency in any of the three members of the VCP/p97-UFD1L … WebOct 11, 2005 · Small VCP/p97-interacting protein Gene names Name Svip Organism names Organism Mus musculus (Mouse) Taxonomic identifier 10090 NCBI Taxonomic lineage … WebMar 6, 2024 · Background: Endoplasmic reticulum-associated protein degradation (ERAD) eliminates misfolded proteins. Numerous illnesses, including cancer, cystic fibrosis, diabetes, and neurological diseases, are influenced by ERAD. ... Investigation of the effects of small VCP-interacting protein (SVIP) on the migration and invasion of breast cancer … shuttlexxyz