Web24 mrt. 2024 · Oxidative stress and oxidative damage are the common pathophysiological characteristics in pituitary adenomas (PAs), which have been confirmed with many omics studies in PA tissues and cell/animal experimental studies. Nuclear factor erythroid 2 p45-related factor 2 (Nrf2), the core of oxidative stress response, is an oxidative stress … Web1 sep. 2024 · Nrf2 is a crucial negative regulator of ferroptosis and acts through modulating various downstream genes, including SLC7A11, FTH1, and GPX4. ... Ferritin protects cells from oxidative stress-induced cell injury caused by redox active-free iron overload.
Nrf2 Mediates the Induction of Ferritin H in Response to …
Web16 mei 2024 · Simultaneously, fumarate increases ferritin gene transcription by activating the NRF2 (nuclear factor [erythroid-derived 2]-like 2) transcription factor. In turn, … WebAntioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 … inez ma mayer brown
Ferroptosis: regulation by competition between NRF2 and BACH1 …
WebAntioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. WebNrf2 not only eliminates ROS by inducing expression of antioxidant genes but also removes iron by FPN1 and neutralizes free iron by ferritin. From this point, Nrf2 exhibits pro-oncogenic activity ( Jung et al., 2024 ). Nrf2 inhibition has attracted more attention on cancer therapy ( Qin et al., 2024 ). Web29 okt. 2024 · NRF2 activation by TBHQ treatment protected against erianin-induced cell death and increased the expression of GPX4, ferritin, xCT and glutaminase. On the … inez malecha northfield