Gata2 elf1
WebGATA2 deficiency is a rare genetic disease that can present as several distinct syndromes: dendritic cell, monocyte, B, and natural killer lymphoid deficiency (monocytopenia and mycobacterial infection syndrome); familial myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML); deafness-lymphedema-leukemia syndrome (Emberger syndrome); or … WebMay 15, 2014 · Gata2 regulates a number of endothelial genes, including PPet1, eNOS, Vecam1, and Endomucin ( Dorfman et al., 1992, German et al., 2000, Gumina et al., 1997, Kanki et al., 2011 ). Ets (E-twenty six) proteins are characterized by an evolutionarily conserved DNA-binding ETS domain.
Gata2 elf1
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WebApr 4, 2024 · GATA2 promotes hematopoietic stem cell emergence in the embryo (21, 22) and hematopoiesis in adult mice (23, 24). Heterozygous GATA2 coding or enhancer germline mutations cause GATA2 deficiency syndrome involving immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia (25–29). WebGATA2 is a hematopoietic factor that has been intensely studied in hematopoietic malignancies. Recently, the functions of GATA2 as an oncogene in other types of human cancer have been reported. However, no role for GATA2 in the development and progression of glioma has been reported to date. In the present study, we found that the …
WebResult of TFs and related markers. From 1 to 10 results，Total 5,905 items. Table Search: Gene Name. Gene Type. Interacting Gene. Cell Name. Cell Type. Tissue Type. Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Web( D ) GATA-2, Fli-1 and Elf-1 bind to the +19 core enhancer but not to exon 6 sequences in vivo . Chromatin immunoprecipitation was performed using the indicated antibodies. The DNA content of the... WebFeb 10, 2011 · Moreover, the Runx1 +23 kb region was shown to be regulated by important haematopoietic TFs (Gata2, Fli1, Elf1, Pu.1, Scl, Lmo2, Ldb1 and Runx1 itself) [53, 54]. Lyl1 is known to contain a promoter region that can be divided into two separate promoter elements that are responsible for driving the expression of Lyl1 within endothelial ...
WebMar 21, 2024 · GATA2 (GATA Binding Protein 2) is a Protein Coding gene. Diseases associated with GATA2 include Immunodeficiency 21 and Lymphedema, Primary, With Myelodysplasia . Among its related …
WebSep 22, 2024 · GATA2 promotes hematopoietic stem and progenitor cell (HSPC) generation and function 11, 42-48 and regulates erythroid and megakaryocytic precursors. 13,49,50 In human embryonic stem cell systems, GATA2 overexpression promotes the conversion of hemogenic endothelium to hematopoietic precursors 51 and maintains multipotent … seesaw kings heathWebGATA2-derived signals were detected in the small vessels of the lung, heart, kidney, and tumour-derived microvascular endothelial cells (data not shown). In cultured endothelial cells, GATA2-positive staining was uniformly found in nuclei (Figure 1D). Genome-wide and cell-type specific GATA2 binding was detected in microvascular endothelial cells seesaw for schools sign inWebApr 26, 2024 · ( A) Model showing the full length MYB with N-terminal 3×Ty1-tag used to generate the current MYB ChIP-seq data from K562 cells. In the model the N-terminal DNA binding domain (DBD), the central... putin\u0027s twitchy footWebDec 30, 2024 · GATA2 ELF1 STAT3 MYC YY1 JUND TCF12: HNF1B (Katoh and Katoh, 2009) rs7957915: chr12:28180501: 2b: GATA2: TAL-1alpha:E47 TAL1 (Katoh and Katoh, 2009) rs17756000: chr14:69019537: 2b: ESR1 FOS GATA2 MAX NR3C1 JUN: AP-4 ASCL2 MEIS1 PKNOX1 PKNOX2 TGIF2 MEIS2 (Stacey et al., 2008) rs4321755: … seesaw learning crunchbaseWebMay 29, 2024 · This Bayesian omics-data fusion based methodology allows to gain a genome-wide picture of the transcriptional interplay, helping to unravel key hierarchical transcriptional interactions, which could be subsequently investigated, and it represents a promising learning approach suitable for multi-layered genomic data integration, given its … see saw hinge bearingWebSep 1, 2024 · Among children, the prevalence of GATA2 deficiency increases with age, and 2/3 of adolescents with MDS and monosomy 7 carry germline GATA2 mutations. In adult MDS, GATA2 deficiency is rare and present in less than 0.5% of individuals [ 52 ], however the true prevalence in various age groups has yet to be defined. seesaw for toddlers age 2-5WebJan 21, 2024 · Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to ... putin\u0027s ussr employer crossword