WebApr 14, 2024 · The addition of all-trans retinoic acid (ATRA) to the standard anthracycline-base chemotherapy has revolutionized the treatment of acute promyelocytic leukemia (APL) over the last decades, becoming a model for precision medicine. The protocols based on the combination of ATRA and chemotherapy allowed obtaining excellent response rates both … WebOct 15, 2024 · HIV-1 Vif plays an essential role in viral replication by antagonizing anti-viral cellular restriction factors, a family of APOBEC3 proteins. We have previously shown that naturally-occurring single-nucleotide mutations in the SA1D2prox region, which surrounds the splicing acceptor 1 and splicing donor 2 sites of the HIV-1 genome, dramatically alter …
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WebIntroduction. Pyoderma gangrenosum (PG) is a chronic, idiopathic, rapidly evolving cutaneous ulcerative condition. It is a non-infectious dermatosis characterized by painful erythematous papules, pustules, or vesicles that rapidly develop into ulcers with ragged, undermined, violaceous, or gunmetal-colored borders [1-3].Approximately 50% of PG are … WebFamily name origins & meanings. Japanese : variously written, usually with characters meaning ‘foot’ and ‘stand’, a habitational name, found mainly in northern Japan, from … health visitors liverpool innovation park
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